Introduction:

Osteoarthritis, a prevalent degenerative joint disorder, significantly impacts the quality of life for millions of individuals worldwide. This study aimed to investigate the potential benefits of a specialized nutritional beverage fortified with milk-based micronutrients, vitamins, and minerals, on alleviating pain symptoms and improving the overall activity levels in adults grappling with osteoarthritis.

Methods:

Thirty-one subjects diagnosed with osteoarthritis in both knees participated in this 6-week study, divided into either the micronutrient-containing beverage group or the placebo group. Subjects in the intervention group consumed 12 oz of the specialized beverage daily, while the placebo group received an identical-looking placebo. Participants were explicitly instructed not to modify their regular activities and diets. Safety was closely monitored by tracking body weights, vital signs, blood chemistries, and adverse events. The primary efficacy assessment utilized the WOMAC composite score derived from the KOOS questionnaire, which was administered weekly.

Results:

Throughout the study, safety indicators exhibited no significant changes in either the micronutrient-containing beverage group or the placebo group, indicating the safety of the intervention. Notably, all KOOS scores displayed significant improvement (P < 0.03) over time in the micronutrient group, while the placebo group demonstrated improvements only in sport function and knee-related quality of life. The overall treatment effect, as determined by changes in the WOMAC composite score, was statistically significant (P = 0.016), with a moderate effect size of 0.555.

Conclusions:

Daily consumption of the specialized nutritional beverage enriched with milk-based micronutrients, vitamins, and minerals showcased notable benefits in alleviating pain symptoms and enhancing functionality in individuals dealing with osteoarthritis. These findings underscore the potential of bioactive micronutrient beverages as a supplementary approach to managing osteoarthritis and improving the well-being of affected individuals. Further research with larger sample sizes and long-term assessments is warranted to corroborate these promising results and ascertain the long-term benefits of such interventions.